EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.52 | (2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ | Staphylococcus aureus | the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt | staphylopine + NADP+ + H2O | - |
? | |
1.5.1.52 | (2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ | Staphylococcus aureus ATCC 700699 | the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt | staphylopine + NADP+ + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.52 | Staphylococcus aureus | A0A0H3JT80 | - |
- |
1.5.1.52 | Staphylococcus aureus ATCC 700699 | A0A0H3JT80 | - |
- |
2.5.1.152 | Staphylococcus aureus | A0A0H3JXA8 | - |
- |
2.5.1.152 | Staphylococcus aureus ATCC 700699 | A0A0H3JXA8 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.52 | (2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ | - |
Staphylococcus aureus | staphylopine + NADP+ + H2O | - |
? | |
1.5.1.52 | (2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ | the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt | Staphylococcus aureus | staphylopine + NADP+ + H2O | - |
? | |
1.5.1.52 | (2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ | - |
Staphylococcus aureus ATCC 700699 | staphylopine + NADP+ + H2O | - |
? | |
1.5.1.52 | (2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ | the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt | Staphylococcus aureus ATCC 700699 | staphylopine + NADP+ + H2O | - |
? | |
2.5.1.152 | S-adenosyl-L-methionine + D-histidine | - |
Staphylococcus aureus | N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine | - |
? | |
2.5.1.152 | S-adenosyl-L-methionine + D-histidine | - |
Staphylococcus aureus ATCC 700699 | N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.5.1.52 | cntM | - |
Staphylococcus aureus |
1.5.1.52 | sav2468 | - |
Staphylococcus aureus |
2.5.1.152 | cntL | - |
Staphylococcus aureus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.52 | NADPH | the enzyme is specific for NADPH | Staphylococcus aureus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.5.1.52 | metabolism | the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt | Staphylococcus aureus |
1.5.1.52 | physiological function | the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt | Staphylococcus aureus |
2.5.1.152 | physiological function | the enzyme participates in the biosynthesis of the metallophore staphylopine. Staphylopine biosynthesis is impaired in the CntL mutant. The import of iron, zinc, nickel, and cobalt are all decreased in CntL mutants. CntL mutant strains are resistant to a concentration of cobalt that is toxic to the wild-type strain | Staphylococcus aureus |